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#!/usr/bin/env -S sh -c '( printf "%s\n" "digraph SomeGraph {"; cat $0; printf "}" ) | dot -v -Tx11 # ikiwiki graphviz.pm sucks'
// connections would optimally be labelled with legitimate correlations
// which would involve something like
// 1) get https://fdc.nal.usda.gov/fdc-datasets/FoodData_Central_foundation_food_json_2025-04-24.zip
// 2) remove broadly inedible "foods" (e.g. dry grains, uncooked meats)
// 3) remove new world foods (e.g. nightshades, sweet potato)
// 4) remove neolithic foods (e.g. grains, legumes, dairy, branded foods)
// 5) group related foods
// 6) group related nutrients
// 7) remove non-essential nutrients besides glutamate while retaining stuff that should
// probably be considered essential, like DHA/EPA/AA, menatetrenone, and collagen
// 8) remove linoleic acid, alpha-linolenic acid, carotinoids, and vitamin D
// 9) run correlations between glutamate and every other nutrient
// 10) remove negative correlations
//digraph Nutrients {
rankdir=LR
newrank=true
node [shape=box, style=filled, fillcolor=white]
subgraph cluster_input_distribution {
label="Training Input Distribution: Selection Effects"
subgraph cluster_receptors {
label="Regulatory\nsensing"
style=filled
fillcolor=lightcoral
node [shape=circle]
T1R1
T1R3
mGluR1
mGluR4
}
"L-Glutamate"
"Cooked\nanimal\ntissues"
subgraph cluster_elements {
label="Essential\nElements"
style=filled
fillcolor=lightgrey
Iron
Zinc // Selective aversion handled by T2R7, T2R14, TRPML1 and/or TRPML3
Iodine
Sulfur
Copper
// Sodium // More directly handled by ENaC
Calcium
// Chlorine // More directly handled by ENaC
Selenium
Potassium
// Chromium // Probably useless
Manganese
Magnesium
Phosphorus
Molybdenum
}
subgraph cluster_amino_acids {
label="Essential\nAmino Acids"
style=filled
fillcolor=tan
Valine
Lysine
Leucine
Histidine
Threonine
Isoleucine
Methionine
Tryptophan
Phenylalanine
}
subgraph cluster_vitamins {
label="Essential\nVitamins"
style=filled
fillcolor=lightblue
"Pantothenic\nAcid"
Pyridoxine
Cobalamin
Riboflavin
Thiamine
Niacin
Biotin
// Presumably anticorrelated
// Folate
// "Vitamin C"
// Phylloquinone
// Essential, but not really nutritional
// "Vitamin D"
// Would be handled in combination with CD36 or the FFARs
// "Retinoic Acid"
// Tocopherols
// Tocotrienols
// Menatetrenone
}
// Better handled by GPR120/FFAR4?
//subgraph cluster_fatty_acids {
// label="Essential\nFatty Acids"
// style=filled
// fillcolor=lightyellow
// "Arachidonic Acid"
// "Eicosapentaenoic Acid"
// "Docosahexaenoic Acid"
//}
// Receptors
{
T1R1
T1R3
mGluR1
mGluR4
} -> "L-Glutamate" -> "Cooked\nanimal\ntissues"
// Connect Glutamate to all fatty acids
// Better handled by GPR120/FFAR4?
//Glutamate -> {
// "Arachidonic Acid"
// "Eicosapentaenoic Acid"
// "Docosahexaenoic Acid"
// } [minlen=1]
"Cooked\nanimal\ntissues" -> {
// Connect Glutamate to all amino acids
Histidine
Isoleucine
Leucine
Lysine
Methionine
Phenylalanine
Threonine
Tryptophan
Valine
} [minlen=2]
// Connect Glutamate to all vitamins
"Cooked\nanimal\ntissues" -> {
Thiamine
Riboflavin
Niacin
"Pantothenic\nAcid"
Pyridoxine
Biotin
// Presumably anticorrelated
// Folate
// "Vitamin C"
// Phylloquinone
Cobalamin
// Essential, but not really nutritional
// "Vitamin D"
// Would be handled in combination with CD36 or the FFARs
// "Retinoic Acid"
// Tocopherols
// Tocotrienols
// Menatetrenone
} [minlen=1]
// Connect Glutamate to all elements
"Cooked\nanimal\ntissues" -> {
Calcium
Phosphorus
Potassium
Sulfur // Maybe Cysteine is more sensible
// Sodium // More directly handled by ENaC
// Chlorine // More directly handled by ENaC
Magnesium
Iron
Zinc // Selective aversion handled by T2R7, T2R14, TRPML1 and/or TRPML3
Manganese
Copper
Iodine
// maybe find a paradigm to exclude supraphysiologic foods like brazil nuts? e.g. when serving size exceeds Institute of Medicine's Dietary Reference Intake max values by a factor of ten or something
Selenium
Molybdenum
// Chromium // Probably useless
} [minlen=3]
}
//}
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