#!/usr/bin/env -S sh -c '( printf "%s\n" "digraph SomeGraph {"; cat $0; printf "}" ) | dot -v -Tx11 # ikiwiki graphviz.pm sucks'
// connections would optimally be labelled with legitimate correlations
// which would involve something like
//  1) get https://fdc.nal.usda.gov/fdc-datasets/FoodData_Central_foundation_food_json_2025-04-24.zip
//  2) remove broadly inedible "foods" (e.g. dry grains, uncooked meats)
//  3) remove new world foods (e.g. nightshades, sweet potato)
//  4) remove neolithic foods (e.g. grains, legumes, dairy, branded foods)
//  5) group related foods
//  6) group related nutrients
//  7) remove non-essential nutrients besides glutamate while retaining stuff that should
//     probably be considered essential, like DHA/EPA/AA, menatetrenone, and collagen
//  8) remove linoleic acid, alpha-linolenic acid, carotinoids, and vitamin D
//  9) run correlations between glutamate and every other nutrient
// 10) remove negative correlations

//digraph Nutrients {
  rankdir=LR
  newrank=true
  node [shape=box, style=filled, fillcolor=white]

  subgraph cluster_input_distribution {
  label="Training Input Distribution: Selection Effects"
    subgraph cluster_receptors {
      label="Regulatory\nsensing"
      style=filled
      fillcolor=lightcoral
      node [shape=circle]
      T1R1
      T1R3
      mGluR1
      mGluR4
    }

    "L-Glutamate"
    "Cooked\nanimal\ntissues"


    subgraph cluster_elements {
      label="Essential\nElements"
      style=filled
      fillcolor=lightgrey
      Iron
      Zinc // Selective aversion handled by T2R7, T2R14, TRPML1 and/or TRPML3
      Iodine
      Sulfur
      Copper
      // Sodium // More directly handled by ENaC
      Calcium
      // Chlorine // More directly handled by ENaC
      Selenium
      Potassium
      // Chromium // Probably useless
      Manganese
      Magnesium
      Phosphorus
      Molybdenum
    }

    subgraph cluster_amino_acids {
      label="Essential\nAmino Acids"
      style=filled
      fillcolor=tan
      Valine
      Lysine
      Leucine
      Histidine
      Threonine
      Isoleucine
      Methionine
      Tryptophan
      Phenylalanine
    }


    subgraph cluster_vitamins {
      label="Essential\nVitamins"
      style=filled
      fillcolor=lightblue
      "Pantothenic\nAcid"
      Pyridoxine
      Cobalamin
      Riboflavin
      Thiamine
      Niacin
      Biotin
  // Presumably anticorrelated
  //  Folate
  //  "Vitamin C"
  //  Phylloquinone
  // Essential, but not really nutritional
  //  "Vitamin D"
    // Would be handled in combination with CD36 or the FFARs
    //    "Retinoic Acid"
    //    Tocopherols
    //    Tocotrienols
    //    Menatetrenone
    }



    // Better handled by GPR120/FFAR4?
    //subgraph cluster_fatty_acids {
    //  label="Essential\nFatty Acids"
    //  style=filled
    //  fillcolor=lightyellow
    //  "Arachidonic Acid"
    //  "Eicosapentaenoic Acid"
    //  "Docosahexaenoic Acid"
    //}

    // Receptors
    {
      T1R1
      T1R3
      mGluR1
      mGluR4
    } -> "L-Glutamate" -> "Cooked\nanimal\ntissues"
    // Connect Glutamate to all fatty acids
    // Better handled by GPR120/FFAR4?
    //Glutamate -> {
    //  "Arachidonic Acid"
    //  "Eicosapentaenoic Acid"
    //  "Docosahexaenoic Acid"
    // } [minlen=1]

    "Cooked\nanimal\ntissues" -> {
    // Connect Glutamate to all amino acids
      Histidine
      Isoleucine
      Leucine
      Lysine
      Methionine
      Phenylalanine
      Threonine
      Tryptophan
      Valine
    } [minlen=2]

    // Connect Glutamate to all vitamins
    "Cooked\nanimal\ntissues" -> {
      Thiamine
      Riboflavin
      Niacin
      "Pantothenic\nAcid"
      Pyridoxine
      Biotin
    // Presumably anticorrelated
    //   Folate
    //   "Vitamin C"
    //   Phylloquinone
      Cobalamin
    // Essential, but not really nutritional
    //   "Vitamin D"
    // Would be handled in combination with CD36 or the FFARs
    //  "Retinoic Acid"
    //  Tocopherols
    //  Tocotrienols
    //  Menatetrenone
    } [minlen=1]

    // Connect Glutamate to all elements
    "Cooked\nanimal\ntissues" -> {
      Calcium
      Phosphorus
      Potassium
      Sulfur // Maybe Cysteine is more sensible
      // Sodium // More directly handled by ENaC
      // Chlorine // More directly handled by ENaC
      Magnesium
      Iron
      Zinc // Selective aversion handled by T2R7, T2R14, TRPML1 and/or TRPML3
      Manganese
      Copper
      Iodine
    // maybe find a paradigm to exclude supraphysiologic foods like brazil nuts? e.g. when serving size exceeds Institute of Medicine's Dietary Reference Intake max values by a factor of ten or something
      Selenium
      Molybdenum
      // Chromium // Probably useless
    } [minlen=3]
  }
//}