blob: 8cf59a7d25c80ea51f9d395f0282d3acab8eab7e (
plain)
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
|
Here are some gene therapy delivery methods.
# naked DNA
# hydrodynamic injection
# viruses and viral gene therapy
* [CAV-2 - why a canine virus is a neurobiologist's best friend](http://easco.org/home/sites/default/files/files_rep/pdf/CAV2why%20a%20canine%20virus.pdf)
# electroporation
# gene gun
# sonoporation
# gas-filled micro-bubbles
# magnetofection and magnetic nanoparticles
* magnetic calcium phosphate nano-formulations
# carbon nanotubes
# quantum dots
* super paramagnetic iron oxide nanoparticles (SPIONS)
# lipoplexes
# dendrimers
# inorganic nanoparticles
* carbon nanotuubes
* magnetic nanoparticles (see also magnetofection)
* calcium phosphate nanoparticles
* gold nanoparticles
* quantum dots
* C60 fullerenes
* aminofullerenes
* silica nanoparticles
# gold nanoparticles
# cell-penetrating peptides
# polymerosomes
# liposomes
# polyplexes (DNA + plastic)
* polyion complex micelles (PICs)
# cationic polymers
* collagen
* albumin
* beta-casein
* zein
# cationic lipids
* dioleylpropyl trimethylammonium chloride (DOTMA)
* dioleoyl trimethylammonium propane (DOTAP)
# cationic emulsions
# solid lipid nanoparticles
# virosomes
# protofection
# natural competence
# Ligandal's nano-gobstopper method
(patent) [Nanoparticle-mediated gene delivery, genomic editing and ligand-targeted modification in various cell populations](https://patents.google.com/patent/CA2924535A1)
conjugation of PEI for DNA binding, histone tail peptide for nuclear localization, poly-glutamic acid, glutamic acid for stabilization and charge balancing or whatever, then you stick DNA to it, and silica coat the whole thing, then add even more cell-targeting stuff to the outside.
# other
* poly lactic-co-glycolic acid (PLGA)-based nanoparticles
* hybrid nanoparticles such as liposome-polycation-DNA (LPD) nanoparticles
* lipopolyplexes
# hplusroadmap logs
See <http://gnusha.org/logs/2017-01-09.log> for some preliminary stuff.
|