HLA-g stuff, feto-maternal stem cells, fertility upregulation genetic changes, delayed age of menopause phenotypeHEADmaster

2 files changed, 14 insertions, 1 deletions

diff --git a/cell_therapy.mdwn b/cell_therapy.mdwn
index d9db165..5df7f01 100644
--- a/cell_therapy.mdwn
+++ b/cell_therapy.mdwn
@@ -300,6 +300,7 @@ Multi-layered approach for immune evasion or resistance:
 
 [Precise and in situ genetic humanization of 6 Mb of mouse immunoglobulin genes](https://www.pnas.org/doi/10.1073/pnas.1323896111)
 
+
 ---
 
 the following is an excerpt from the [[xenotransplantation]] page:
@@ -335,6 +336,12 @@ Immusoft clinical trials? apparently these are not patient-derived cells?
 
 [Fetoplacental extracellular vesicles deliver conceptus-derived antigens to maternal secondary lymphoid tissues for immune recognition](https://pmc.ncbi.nlm.nih.gov/articles/PMC12128977/)
 
+a proposal to use (naturally allogeneic) fetal-maternal stem cells to replace [[aging]] brain cells one-at-a-time <https://sundialtx.substack.com/p/next-gen-cell-therapies-are-already>
+
+[Multipotent fetal-derived Cdx2 cells from placenta regenerate the heart](https://pmc.ncbi.nlm.nih.gov/articles/PMC6576083/) in an unrelated adult individual without requiring immunosuppression.
+
+"expressing the HLA-G phenotype downregulates T and NK cell activity to protect the fetus from the maternal immune system; turns out the same pathway works in unrelated individuals."
+
 what about using pregnancy as a way to trigger immunotolerance or immunocompatible allotransplantation, with actual pregnancy from donor?
 
 what about understanding the route that pregnancy takes for immunocompatibility and hijacking it to execute even without a real pregnancy?
diff --git a/genetic-modifications.mdwn b/genetic-modifications.mdwn
index b1cc422..e338bd4 100644
--- a/genetic-modifications.mdwn
+++ b/genetic-modifications.mdwn
@@ -933,6 +933,8 @@ rs246185 near MKL2 on chromosome 16p13.12 might be associated with 2.1 weeks ear
 
 breast size: <http://www.snpedia.com/index.php/Breast_size> and <a href="http://www.biomedcentral.com/1471-2350/13/53/abstract">ref</a> - see rs7816345, rs4849887, rs17625845, rs12173570, rs7089814, rs12371778, rs62314947, rs7089814(C;C), rs4665972(C;C), rs4849887(C;C), rs2819348(T;T), rs17356907(A;A), rs34479159(T;T), rs10488023(A;A), rs61159171(C;C), rs61280460(A;T), rs4820792(C;C), rs7837045(A;C), rs17625845(T;T), rs1529102(C;T), rs7102705(A;G), rs7104745(A;A), rs12585963(A;A), rs62314947(C;T)
 
+rs13196892 located between genes TXNDC5 and MUTED is associated with delayed age of menopause, as is rs6467223 in TNPO3
+
 # Muscular strength
 
 <https://www.biorxiv.org/content/early/2017/10/10/201020>
@@ -969,6 +971,8 @@ see <http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.10032
 
 ## pregnancy
 
+TODO: increase predisposition to twinning or maternal-utero compatibility with pregnancies of multiples. see also fertility upregulation in the TODO section below. see also [[in vitro fertilization]] (WIP).
+
 ### Reduced morning sickness during pregnancy
 
 * heightened morning sickness and vomiting: rs1891246, rs790899 -- see <a href="http://www.helpher.org/HER-Research/downloads/2016%20Fejzo%20Genetic%20analysis%20of%20hyperemesis%20gravidarum%20reveals%20association%20with%20intracellular%20calcium%20release%20channel%20RYR2.pdf">Genetic analysis of hyperemesis gravidarum reveals association with intracellular calcium release channel (RYR2)</a>
@@ -1369,11 +1373,13 @@ What about radiation resistance? Here's a case in the literature where radiation
 
 * disable menstruation
 
+* optional or delayed menopause, such as through [ovarian time travel](https://gnusha.org/logs/2025-09-08.log) where you cryopreserve one of the ovaries early in life and then implant it 50 years later to use your younger ovary later.
+
 * voluntary infertility (you'd be making a bet on the development of assisted reproduction technologies in the future, such as creating sperm or eggs from skin cells) (many infertility-causing mutations are known)
 
 * optional or delayed puberty (trigger puberty later or whenever the child wants- wait 5 years? 20 years?)
 
-* fertility upregulation, such as early ovarian hypertrophy during gestation, enhanced ovarian reserves such as through <a href="https://www.nature.com/articles/ncomms2861">Foxo3 overexpression</a>; enable or upregulate post-natal oogenesis (human postnatal oogenesis is currently a science community controversy with no scientific consensus).
+* fertility upregulation, such as early ovarian hypertrophy during gestation, enhanced ovarian reserves such as through <a href="https://www.nature.com/articles/ncomms2861">Foxo3 overexpression</a> or oocyte-specific deletion of Petn to cause premature follicular activation, or disabling Hippo, FSH overexpression to increase fertility, disable AMH to increase fertility, or other interventions to cause massive oocyte activation; enable or upregulate post-natal oogenesis (human postnatal oogenesis is currently a science community controversy with no scientific consensus).
 
 * blood types