fix hedonic reward encoding modification proposal; encode neuronal protein bits for brain uploading reasons.HEADmaster

1 files changed, 4 insertions, 2 deletions

diff --git a/genetic-modifications.mdwn b/genetic-modifications.mdwn
index ecb97c6..9ceb03d 100644
--- a/genetic-modifications.mdwn
+++ b/genetic-modifications.mdwn
@@ -355,9 +355,9 @@ signal - GNAT3, TRPM5, PLCB2
 
 bitterness - T2R - TAS2R4, TAS2R5, TAS2R16, TAS2R8, TAS2R38, TAS2R48 see also <a href="https://www.biorxiv.org/content/early/2018/04/06/296269">ref</a>
 
-Taste is GPCRs (G-protein coupled receptors) and some ion channels. Taste perception goes from receptors -> cranial nerves VII, IX, X -> solitary nucleus -> thalamus -> gustatory cortex.
+Taste is GPCRs (G-protein coupled receptors) and some ion channels. Taste perception goes from receptors -> cranial nerves VII, IX, X -> solitary nucleus -> thalamus -> gustatory cortex. Actually that might be wrong, see <https://gnusha.org/logs/2025-10-02.log> for more details. For hedonic reward from taste: parabrachial nucleus interneurons need to be modified for hedonic reward association against endocrine-linked nutrient sensors on those neurons. Positive hedonic gustatory value is encoded here by "high gamma phase locking" with ~something in VPMpc/BLA that starts a timing window initialized by orofacial sensorimotor pattern generator, anyway they watch for an expected spike and if it's late a FoxP2+ GABAergic interneuron in VPMpc is already depolarized or something. Maybe better to modify VPMpc interneurons to couple spike decision with internal nutritional deficiency status sensing?
 
-TODO: look at olfactory perception enhancement proposals on this page and apply to taste as well?
+TODO: look at olfactory perception enhancement proposals on this page and apply to taste as well? The actual circuit for hedonic value of olfactory perception has not been documented here yet.
 
 let a new era of total gluttony now commence.
 
@@ -1542,6 +1542,8 @@ Various genomically encoded nanobodies can be expressed for antibody-based taggi
 
 Consider anything that would help with postmortem [[expansion microscopy]] for [[brain imaging]].
 
+review [PRISM](https://www.biorxiv.org/content/10.1101/2025.09.26.678648v1) for any other changes that would be beneficial to genomically encode, such as their GFP-fused "protein bits" that space-fill each neuron with a random neural barcode driven by Cre-lox (or polylox barcoding or CRISPR-based barcoding) lineage randomization. It would be interesting if the "protein bits" could be combined with [connectome-seq](https://www.biorxiv.org/content/10.1101/2025.02.13.638129v2.abstract) migration of pre-synaptic and post-synaptic RNA barcodes into the synaptic junction for connectome recovery via sequencing. The combination could be achieved, possibly, by having some sort of relationship between the RNA barcode and the abstract bit-vector from the set of "protein bits" expressed by that neuron.
+
 <a name="longevity" />
 # Longevity